Ingqikithi yokupholisha amakhemikhali ifana naleyo yokupholisha nge-electrolytic, okubuye kube inqubo yokuncibilika kwendawo. Umthelela wokuncibilika okhethiwe wama-reagents amakhemikhali ezindaweni ezingalingani ebusweni bamasampuli kuyindlela yokuqeda izimpawu zokuguga, ukuguguleka kanye nokulinganisa.

Izinzuzo zokupholisha ngamakhemikhali: imishini yokupholisha ngamakhemikhali ilula, ingakwazi ukuphatha ukuma kwezingxenye eziyinkimbinkimbi.

Ububi bokupholishwa kwamakhemikhali: ikhwalithi yokupholisha ngamakhemikhali ingaphansi kweyokucwecwa ngogesi;Ukulungiswa nokuvuselelwa kwesixazululo esisetshenziswa ekupholiseni amakhemikhali kunzima futhi kukhawulelwe ekusebenzeni.Enqubweni yokupholisha ngamakhemikhali, i-nitric acid ikhipha igesi eningi eyingozi ephuzi nensundu, ebangela ukungcoliswa okukhulu kwemvelo.